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اللي عنده معلومات عن Leukemoid reaction يساعدني

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  • اللي عنده معلومات عن Leukemoid reaction يساعدني

    مراااااحب
    هاذي الاسئله
    what is Leukemoid reaction

    :what are the causes of leukemoid reaction

    what important laboratory tests would you preform to diagnose leukemoid reaction?




  • #2
    what is Leukemoid reaction
    A leukemoid reaction is an increase in white blood cell count similar to what occurs in people with leukemia. However, the reaction is actually due to an infection or another disease and is not a sign of cancer


    what are the causes of leukemoid reaction

    *

    Electromagnetic, Physics, trauma, Radiation Causes
    o Electrocution/lightning strike

    *

    Surgical, Procedure Complication
    o Splenectomy, immediate postoperative

    *

    Infectious Disorders (Specific Agent)
    o Pneumonia, bacterial
    o Immune deficiency , acquired (AIDS/HIV)
    o Trichinosis
    o Tuberculosis, disseminated
    o Visceral larval migrans
    o Pertussis
    o Trichinella, acute infestation
    o Hanta virus/Navaho disease
    o Malaria

    *

    Infected organ, Abscesses
    o Empyema
    o Pneumonia

    *

    Neoplastic Disorders
    o Hodgkin's disease
    o Adenocarcinoma, gastric
    o Adenocarcinoma, pancreatic
    o Carcinoma, bronchogenic
    o Myeloproliferative disease
    o Hypereosinophilic syndrome

    *

    Allergic, Collagen, Auto-Immune Disorders
    o Hypersensitivity pneumonitis/alveolitis

    *

    Metabolic, Storage Disorders
    o Diabetic ketoacidosis/coma

    *

    Deficiency Disorders
    o Dehydration and fever
    o Dehydration

    *

    Usage, Degenerative, Necrosis, Age Related Disorders
    o Hepatic necrosis, acute/subacute

    *

    Arteriosclerotic, Vascular, Venous Disorders
    o Cerebral thrombosis
    o Mesenteric artery embolism

    *

    Vegetative, Autonomic, Endocrine Disorders
    o Thyrotoxic crisis

    *

    Reference to Organ System
    o Hemolysis process
    o Hemolytic Anemia

    *

    Drugs
    o Corticosteroid Administration/Toxicity

    *

    Poisoning (Specific Agent)
    o Hepatitis, alcoholic


    what important laboratory tests would you preform to diagnose leukemoid reaction

    leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction. However, at present the test of choice in adults to distinguish CML is an assay for the presence of the Philadelphia chromosome, either via cytogenetics and FISH, or via PCR for the BCR/ABL fusion gene. The LAP (Leukocyte Alkaline Phosphatase) score is high in reactive states but is low in CML
    :extra77:

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    • #3
      Conventionally, a leukocytosis exceeding 50,000 WBC/mm3 with a significant increase in early neutrophil precursors is referred to as a leukemoid reaction.[1] The peripheral blood smear may show myelocytes, metamyelocytes, promyelocytes, and even myeloblasts; however, there is a mix of early mature neutrophil precursors, in contrast to the immature forms typically seen in acute leukemia. Serum leukocyte alkaline phosphatase is elevated in leukemoid reaction, but is depressed in chronic myelogenous leukemia. The bone marrow in a leukemoid reaction, if examined, may be hypercellular but is otherwise typically unremarkable.

      Leukemoid reactions are generally benign and are not dangerous in and of themselves, although they are often a response to a significant disease state (see Causes below). However, leukemoid reactions can resemble more serious conditions such as chronic myelogenous leukemia (CML), which can present with identical findings on peripheral blood smear.

      Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction. However, at present the test of choice in adults to distinguish CML is an assay for the presence of the Philadelphia chromosome, either via cytogenetics and FISH, or via PCR for the BCR/ABL fusion gene. The LAP (Leukocyte Alkaline Phosphatase) score is high in reactive states but is low in CML. In cases where the diagnosis is uncertain, a qualified hematologist or oncologist should be consulted.

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      • #4
        مرحبا dr.moz
        شاكره لك جهودك اللي بذلته معي
        الله يعطيك ألف عافيه
        :more20:

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        • #5
          اهلاً ahmedzein4
          الله يسلم لي ايدينك على المعلومات
          مشكور والله يجزاك ألف خير
          :more12:

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          • #6
            DR.pink
            عندي معلومات تفيدك عن الموضوع
            برفقها في ملف قريباً
            للتواصل : hoot-mall@hotmail.com

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            • #7
              شكرا يا دكتووووووور جابر لا تكلف على عمرك وووصلت المعلومات من اصحاب الخير
              :sm185:

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              • #8
                شكرh dr.moz على المعلومات الرائعه
                TECHNOLOGIST

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