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لا يوجد إعلان حتى الآن.
مين ممكن يحلها؟
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Philadelphia chromosome
is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t(9;22)(. The presence of this translocation is a highly sensitive test for CML
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المشاركة الأصلية بواسطة hematologist مشاهدة المشاركةPhiladelphia chromosome
is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t(9;22)(. The presence of this translocation is a highly sensitive test for CML
نبي الكلام كله............................. يلة كمله.........من طلب العلا سهر الليالي
تعليق
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المشاركة الأصلية بواسطة hematologist مشاهدة المشاركةهذا كل ما لدي يا دكتور
من طلب العلا سهر الليالي
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المشاركة الأصلية بواسطة samah ahmed مشاهدة المشاركةالاسئله صعبه اللى بقدر عليها بجاوب وانا دائما متابعه للاسئله واستفدته كثير مشكورمن طلب العلا سهر الليالي
تعليق
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yes , there is chromomsomal abnormalities (9;22) chromosomes
اكتر من 90%من حالات CMLتتميز بمجود مثل هذه الحالة وهي ما تسمى philadelphia chromosomeالمشكلة ان هذا التركيب يؤدي الى تكوين مايسمىoncogenic protein
اكيد تواجد مثل هذا النوع يعطي bad prognosis
تعليق
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الحل الكامل لهذه الحالة هو:
This karyotype shows a reciprocal translocation between chromosome 9 and 22, this type of translocation is called Pheladelphia chromomosome (Ph) this causes a fusion between two genes, the ABL gene and the BCR gene, this fusion causes the production of a chimeric protein product that has a tyrosine kinase activity, that has an oncogenic activity and causes uncontrolled proliferation of cells, especially the myeloid series.
It is true that more than 90% of CML cases (chronic myelocytic leukemia, also called chronic granulocytic leukemia) shows this type of translocation that is called Pheladelphia chromosome. But also this type of chromosome translocation (Pheladelphia chromosome) is seen in some cases of ALL (acute lymphocytic leukemia) especially childhood ALL, and carry a very bad prognosis
It is worthy to know also that about 5% of CML cases that is Pheladelphia chromosme negative has the fusion gene (ABL/BCR) and thus has the same consequences asif the pheladelphia chromosome is present.
In karyotypes at least 4 Mb should be changed to be able to see chromosomal abberations or abnormalities.
Thank you very much
Ashraf Shaqalaih
:sm183::sm183::sm183:من طلب العلا سهر الليالي
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