hypersegmented neutrophil

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Here is a hypersegmented neutrophil that is present with megaloblastic anemias. There are 8 lobes instead of the usual 3 or 4. Such anemias can be due to folate or to B12 deficiency. The size of the RBC's is also increased (macrocytosis, which is hard to appreciate in a blood smear).



This hypersegmented neutrophil is present along with macro-ovalocytes in a case of pernicious anemia. Compare the size of the RBC's to the lymphocyte at the lower left center.

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[فيصل]

Hypersegmented neutrophil

Hypersegmented neutrophils are neutrophils with 5 or more nuclear lobes. They are seen in disorders of nuclear maturation, such as the megaloblastic anemias.

[lab.com]

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[HIV]

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The normal neutophile has 3-5 lobes....
Also hypersegmented cell can not defense as usuall neutrophile

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لاب كوم

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[ramimy]

Hypersegmented neutrophils also could be found rarely in iron defeciency anaemia(Hoffbrand, Postgraduate haematology) & this may cause some confusion with cases of mixed nutritional defeciency anaemia if no macrocytosis appear, your correspondance please.

[MBSc. Mohammad]

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