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DHEAS.. GENERAL INFORMATION

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  • DHEAS.. GENERAL INFORMATION

    [DHEAS

    DE HYDRO EPI ANDROSTERONE SULFATE


    Dehydroepiandrosterone sulfate


    How is it used?
    DHEAS levels are not routinely measured. Unless you have symptoms that warrant its use, you will most likely never have a DHEAS test done. DHEAS, testosterone, and several other androgens are used to evaluate adrenal function and to distinguish between androgen secreting adrenal conditions from those that originate in the ovary or testes. DHEAS can be measured to help diagnose adrenocortical tumors (tumor in the cortex of the adrenal gland), adrenal cancers, and adrenal hyperplasia (which may be congenital or adult onset) and to separate them from ovarian tumors and cancers.

    Concentrations of DHEAS are often measured, along with other hormones such as FSH, LH, prolactin, estrogen, and testosterone, to help diagnose polycystic ovarian syndrome (PCOS) and to help rule out other causes of infertility, amenorrhea, and hirsutism.

    DHEAS levels may be ordered, along with other hormones, to investigate and diagnose the cause of virilization\\الاسترجال\\ in young girls and precocious puberty in young boys.



    When is it ordered?
    DHEAS may be ordered, along with other hormones, whenever excess (or more rarely deficient) androgen production is suspected and/or when your doctor wants to evaluate your adrenal gland function.

    It may be measured when a woman presents with symptoms such as: hirsutismشعر قاسي, alopecia (hair loss), amenorrhea, infertility, acne, increased muscularity, and decreased breast size. It may also be ordered when a young girl shows signs of virilization, such as hirsutism, a deep voice, or when a female infant has ambiguousغامض genitalia wherein the clitoris is overgrown, but the internal female organs usually appear normal.

    DHEAS may also be measured when young boys show signs of precociousمبكر نضوج puberty - the development of: a deeper voice, pubic hair, muscularity, and an enlarged penis well before the age of normal puberty.



    What does the test result mean?
    NOTE: A standard reference range is not available for this test. Because reference values are dependent on many factors, including patient age, gender, sample population, and test method, numeric test results have different meanings in different labs. Your lab report should include the specific reference range for your test. Lab Tests Online strongly recommends that you discuss your test results with your doctor. For more information on reference ranges, please read Reference Ranges and What They Mean.
    Low levels of DHEAS may be due to adrenal dysfunction or hypopituitarism - a condition that causes decreased levels of the pituitary hormones that regulate the production and secretion of adrenal hormones. Normal DHEAS levels, along with other normal androgen levels, may indicate that the adrenal gland is functioning normally, or (more rarely) that the adrenal tumor or cancer present is not secreting hormones. Normal levels of DHEAS may be seen with PCOS, as this disorder is usually related to ovarian androgen production (primarily testosterone).


    Elevated levels of DHEAS, in conjunction with elevations in such tests as 17-ketosteroids (which measures androgen metabolites in urine) and 17-OH progesterone may indicate an adrenocortical tumor, adrenal cancer, or adrenal hyperplasiaتكاثر لخلايا الغدة. Increased levels of DHEAS usually indicate the need for further testing to pinpoint the cause of the hormone imbalance, but do not often stand alone for diagnostic purposes.


    Is there anything else I should know?
    DHEAS levels are normally high in both male and female newborns. They drop sharply shortly after birth, then rise again during puberty. DHEAS concentrations peak after puberty, and then, like other male and female hormones, the levels tend to decline as we age.





    1. Does everyone with elevated DHEAS have symptoms?
    Not necessarily. It may be difficult to determine when adult men have elevated levels of DHEAS (since they already have masculineذكوري secondary sexual characteristics) and women of some ethnic groups (for example Asian women) may have elevated levels of testosterone and DHEAS without exhibiting symptoms such as excess hair growth or acne. Also, it should be noted that the symptoms present, and their severity, will vary from person to person.



    2. How is excess DHEAS treated?
    Increased DHEAS levels are addressed by diagnosing and treating the underlying cause. Surgery may be necessary to remove adrenal tumors or cancers. If the affected adrenal gland is entirely removed, the ovaries, testes, and the remaining adrenal gland can still sufficiently produce hormones. Medications such as antiandrogens, low-dose oral contraceptives, and fertility drugs like clomiphene citrate may be used to counter the effects of excess androgens. Low–dose contraceptives help to balance female and male hormones and to restore regular menstruation, while fertility drugs (ex. Clomid) can help to induce ovulation.
























    What is being tested?
    Dehydroepiandrosterone sulfate (DHEAS) is a sex hormone (androgen) created in men and to a lesser extent, women. It has a role to play in developing male secondary sexual characteristics at puberty and it can be metabolized by the body into more potent androgens, such as: testosterone and androstenedione, or changed into the female hormone estrogen. DHEAS is produced primarily in the adrenal cortex - the outer portion of the adrenal gland - with much smaller amounts coming from the woman's ovaries and man's testes. DHEAS secretion is controlled by adrenocorticotropic hormone (ACTH) and other pituitary factors.
    Since DHEAS is primarily produced by the adrenal glands, it is useful as a marker for adrenal function. Adrenal tumors, cancers, and hyperplasia (excess growth of hormone producing tissue) can lead to the overproduction of DHEAS. While elevated levels may not be noticed in adult men, they can lead to amenorrhea and visible symptoms of virilization (development of physical masculine characteristics) in women. These changes vary in severity and may include: a deeper voice, hirsutism - excess hair growth on face or body, male pattern baldness, muscularity, and acne. Excess levels of DHEAS in children can cause precocious puberty in boys; and ambiguous external genitalia, excess body hair, and abnormal menstrual periods in girls.

    How is the sample collected for testing?
    A blood sample is obtained by inserting a needle into a vein in the arm. As an alternative, particularly in pediatric care, the blood sample is drawn from the fingertip. This is often called a "fingerstick".
    NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.
    Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.
    انا الذي نظر العمى إلى ادبــي **** و أسمعـت كلماتي من به صمــم

  • #2
    السلام عليكم ورحمة الله وبركاته

    شكرا ليك عالموضوع جزاك الله خيرا

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    • #3
      gzak allah kheir

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      • #4
        مشكور يا اخي

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        • #5
          very interested subject
          thank you so much

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          • #6
            thanksssssssssssssssssssss
            إذا أردت أن تعيش سعيداً .. إنزع الحقد من قلبك

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