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VDRL AND TPHA

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  • VDRL AND TPHA

    WHAT IS THE CASES THAT THE TPHA TEST IS POSITIVE AND THE VDRL NEGATIVE ?

  • #2
    المشاركة الأصلية بواسطة amjad_a مشاهدة المشاركة
    WHAT IS THE CASES THAT THE TPHA TEST IS POSITIVE AND THE VDRL NEGATIVE ?
    False positive reaction of TPHA ; due to other spirochetace
    تواضع تكن كالنجم لاح لناظر على صفحات الماء وهو رفيع

    و لا تك كالدخان يعلو بنفسه على طبقات الجو و هو وضيع


    http://up1.m5zn.com/photo/2009/2/10/...okezwv.gif/gif

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    • #3
      this question was a test for all ? no one can know this cases by him self but i know the answer
      and it is:
      (a)Acute biological false positive cases which can be due to viral, bacterial infection, vaccination and immunization, malarial parasite.

      (b)Chronic biological false positive cases which are due to SLE, cardiovascular diseases, autoimmune disorders. 70% of them are women. The other group of weakly positive cases may be that the patient is suffering from syphilis either in 1st or 3rd stage of disease and those who have taken irregular or partial treatment. To differentiate them TPHA is very important since it is negative in biological false positive cases and positive in early 1st stage and in 3rd stage of syphilis and remain positive even after treatment. The instances where VDRL negative and TPHA positive, may be the fully treated patient and in case of non-venereal treponemal infection. Infant born to mother having syphilis. and being treated during pregnancy also show variable status of VDRL. Again the TPHA may be useful in concluding whether the infant should be treated or not. If the infant is TPHA positive in early weeks of life a repeat TPHA after 1 month may illustrate positive status of infant. Moreover TPHA should be done in blood transfusion products as VDRL may be weak positive or may be prozone phenomenon and be falsely interpreted as negative.
      thx to all

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