تويت
Anti-cardiolipin antibodies (ACA)
are antibodies often directed against cardiolipin and found in several diseases including syphilis[1], antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome[2], idiopathic spontaneous abortion,[3] and systemic lupus erythematosus(SLE).[4] They are a form of anti-mitochondrial antibody. In SLE, The anti-DNA antibodies and anti-cardiolipin act independently.[5] In rheumatoid arthritis[6] w/systemic sclerosis (scleroderma)[7] these antibodies may tie two conditions together.
Anti-cardiolipin antibodies come can be classified in two ways.
As IgM, IgG or IgA
As β2-glycoprotein dependent or independent
In autoimmune disease ACA are beta-2 glycoprotein dependent
syphilis ACA[1] are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test
[edit]Apolipoprotein H involvement
β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[8] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
are antibodies often directed against cardiolipin and found in several diseases including syphilis[1], antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome[2], idiopathic spontaneous abortion,[3] and systemic lupus erythematosus(SLE).[4] They are a form of anti-mitochondrial antibody. In SLE, The anti-DNA antibodies and anti-cardiolipin act independently.[5] In rheumatoid arthritis[6] w/systemic sclerosis (scleroderma)[7] these antibodies may tie two conditions together.
Anti-cardiolipin antibodies come can be classified in two ways.
As IgM, IgG or IgA
As β2-glycoprotein dependent or independent
In autoimmune disease ACA are beta-2 glycoprotein dependent
syphilis ACA[1] are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test
[edit]Apolipoprotein H involvement
β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[8] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
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What are Cardiolipin Antibodies?
Cardiolipin antibodies are proteins found in your body that work against cardiolipin. Cardiolipin is a molecule found in your blood platelets and various cell membranes. It is one of a group of molecules called phospholipids. You need cardiolipin in order to help regulate blood clotting throughout your body. Sometimes though, your body can mistake cardiolipin for an attacking substance. As a result, your body creates soldier-like molecules to fight against the cardiolipin.
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