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مساعدة: مجموعه اسئله تحتاج الاحابه

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  • مساعدة: مجموعه اسئله تحتاج الاحابه

    السلام عليكم ورحمة الله وبركاته

    مسسآءء\صبآآح الخــير

    توجــد لدي بعض الأسـئلة في مـآدة الهيمآتولوجي آرجوو التكــرم وحلهــآ :sm173:


    1- What type of iron is found in normal hemoglobin?
    2- What protein is the main carrier of free hemoglobin in the plasma?
    3- List the three hemoglobins found in normal adult blood and state how much of each is present.
    4- Which hemoglobin is present in the highest amount in newborns?

    5-What are the dimensions of a Newbauer hemacytometer on one side of the counting chamber?
    b. What is the depth of the Newbauer hemacytometer?
    c. What is the depth factor used in calculations?


    7- For a manual RBC count,
    a. what squares of a Newbauer hemacytometer are used?
    b. what is the total area of the counting squares?
    c. what diluent is used?
    d. what is the normal dilution?

    8. For a manual WBC count,
    a. what squares of a Newbauer hemacytometer are used?
    b. what is the total area of the counting squares
    c. what diluent is used?
    d. what is the normal dilution ?


    10- For each of the following RBC indices, write the formula for calculation and the normal reference range.
    a. MCV
    b. MCH


    11-
    a. Which RBC indice is used to determine cell size?
    b. Which RBC indice is used to determine hemoglobin content?
    c. Which RBC indice is used to express variation in RBC size?

    12- What is the life span of a platelet?
    13- What is the life span of red blood cells?
    14- What is the life spans of neutrophiles?
    Monocytes?

    15- For each of the following types of anemia, state the morphology of the RBCs.
    a. Acute blood loss
    b. Anemia of chronic disease
    c. Aplastic anemia
    d. B12/folate deficiency
    e. Beta Thalassemia
    f. Chronic blood loss
    g. Iron deficiency
    h. Sickle cell


    16- Which anemia is associated with the following finding on the peripheral smear?


    a. hypersegmented PMNs
    b. target cells
    c. Heinz bodies
    17- What amino acid substitution in the globin chains is seen with each of the following. Be specific.
    a. sickle cell anemia
    b. Hemoglobin C disease

    18-Which anemia is diagnosed using the following tests?
    e. Coomb's test.
    d. antibodies to Intrinsic factor
    c. Ham’s test
    b. Osmotic fragility
    a. Schilling test

    19-State the normal value for the following Hematology tests.
    Diff
    Hematocrit
    Hemoglobin
    Platelet
    RBC
    RDW
    Retic
    WBC





    22- Target cells are seen in cases of:
    a- folic acid deficiency
    b- Iron deficiency anemia
    c- Vit B12 deficiency anemia
    d- Thalassemia


    24- Schilling test is done in diagnosis of:
    a- iron deficiency anemia
    b- Pernicious anemia
    c- Aplastic anemia
    d- folic acid deficiency





    40- All of the following is correct regarding spherocytosis except:
    a- normocytic normochromic anemia
    b- Decreased reticulocyte count
    c- Raised plasma bilirubin
    d- Increased osmotic fragility






    45- Fanconi’s anemia is a type of :
    a - vit B12 deficiency
    b- aplastic anemia
    c- Thalassemia
    d- folic acid deficiency anemia




    68-Thalassemia due to increase of
    a) Hb A
    b) Hb F
    c) Hb A2
    d) Hb S


    71-Which of the following types of anemia is generally normocytic?
    a) Pernicious anemia
    b) Sideroblastic anemia
    c) Anemia of chronic disease
    d) Iron deficiency anemia
    e) Sickle cell anemia





    74-Damage to the ileum, preventing nutrient absorption, would cause which of the
    following forms of anemia?
    a) Deficiency of iron
    b) Deficiency of folic acid
    c) Deficiency of vitamin B12
    d) Deficiency of pyruvate kinase
    e) Deficiency of G6PD


    75-Damage to the jejunum, preventing nutrient absorption, would cause which of the
    following forms of anemia?
    a) Deficiency of iron
    b) Deficiency of folic acid
    c) Deficiency of vitamin B12
    d) Deficiency of pyruvate kinase
    e) Deficiency of G6PD


    76-Alpha-thalassemias are most commonly caused by ____ and beta-thalassemias are
    most commonly caused by ____.
    a) Insertions; Deletions
    b) Deletions; Point mutations
    c) Point mutations; Repeat sequence mutation
    d) Repeat sequence mutation; Insertions
    e) Point mutations; Deletions





    78-Antibodies against intrinsic factor can cause which of the following nutritional
    deficiencies?
    a) Combined folate and vitamin B12
    b) Folate
    c) Iron
    d) Vitamin B12
    e) Combined iron and folate


    82-Lab values return for a patient with possible microcytic anemia. The results are
    normal mean corpuscular volume (MCV), decreased RBCs, TIBC 250mcg/dL, increased ferritin with 17% transferritin saturation, and increased marrow iron. Which of the following is most likely?
    a) Iron deficiency anemia
    b) Anemia of chronic disease
    c) Sideroblastic anemia
    d) Lead poisoning
    e) Thalassemia







    83- Lab values return for a patient with possible microcytic anemia. The results are
    decreased mean corpuscular volume (MCV), decreased RBCs, TIBC 350mcg/dL, low
    ferritin with 7% transferritin saturation, and absent marrow iron. Which of the following
    is most likely?
    a) Iron deficiency anemia
    b) Anemia of chronic disease
    c) Sideroblastic anemia
    d) Lead poisoning
    e) Thalassemia


    87-Fanconi aneamia is :
    a) Acongenital aplastic aneamia.
    b) Aneamia due hemoglopinopathy.
    c) Acquired aneamia.
    d) Autoimmune hemolytic aneamia.
    e) None of the above.





    92- What are the features of Fanconi aneamia?


    93-All of the following are causes of qualitative defect of hemoglobin except ?
    a) Hemoglobin S
    b) Hemoglobin C
    c) Hemoglobin E
    d) Hemoglobin D
    e) Thalasseamia.

    94- Which of the following cause Rhomboid shape crystals in the RBCs?
    a) Hemoglobin S
    b) Hemoglobin C
    c) Hemoglobin E
    d) Hemoglobin D
    e) Thalasseamia.

    95- What is the hemoglobin abnormality in Hemoglobin S?
    96- What is the hemoglobin abnormality in Hemoglobin D?
    97- What is the hemoglobin abnormality in Hemoglobin E?
    98 - What is the hemoglobin abnormality in Hemoglobin C?

    99-Which of the following aneamias cause autosplenectomy?
    a) Thalaseamia
    b) Sickle cell aneamia
    c) Autoimmune hemolytic aneamia
    d) Aplastic aneamia
    e) Spherocytosis.





    102-The most common cause of death in adult with sickle cell aneamia is
    a) Aplastic crisis
    b) Vaso-occlusive crisis
    c) Gall bladder stones
    d) Acute chest syndrome
    e) All of the above.

    103- Painful crises in patient with sickle cell aneamia is due to
    a) Aplastic crisis
    b) Vaso-occlusive crisis
    c) Gall bladder stones
    d) Acute chest syndrome
    e) All of the above.

    104-Hand foot syndrome is seen in ?
    a) Thalaseamia
    b) Sickle cell aneamia
    c) Autoimmune hemolytic aneamia
    d) Aplastic aneamia
    e) Spherocytosis.

    105-Hand foot syndrome is due to ?
    a) Aplastic crisis
    b) Vaso-occlusive crisis
    c) Gall bladder stones
    d) Acute chest syndrome
    e) All of the above

    107-Regarding - -/- - 4 α_genes deleted, Which of the following statements is true?
    a) No α_ chains produced
    b) Mainly γ forms tetramers (4 _γ )
    c) Called Bart’s hemoglobin.
    d) Intrauterine death or stillborn.
    e) All of the above .

    108- Regarding - -/ -_ 3α_ genes deleted, Which of the following statements is true?
    a) Called Hb H disease(β4 is termed Hb H)
    b) Cause Chronic haemolytic anaemia
    c) Reduced α_ chain production with formation of β4 tetramers
    d) Reduced mean cell volume and mean corpuscular haemoglobin
    e) All of the above.

    Note the pathophysiology of α thealasseamia and the formation of Bart's hemoglobin and Hemoglobin H disease.


    109- What is the site of hematopoiesis in ?
    Adult
    Children
    Infant
    Fetus.

    110- What is the meaning of extra-medullary hematopoiesis?
    111- What is the definition of growth factors?
    112- Enumerate 5 examples of growth factors?
    113- What are the features of growth facors?
    114-The bone marrow is composed of bone marrow cells and stromal cells?
    What are the bone marrow cells, and what are the stromal cells/
    115- The erythropoiesis is controlled mainly by erythropoietin ,
    what is erythropoietin?
    116-What is the differences between RBCs, Reticulocytes, normoblast?
    116- What are the factors which increase erythropoietin secretion?
    117- What are the factors which shift oxygen-hemoglobin dissociation curve to the right?
    118- What is the meaning of shifting the oxygen-hemoglobin dissociation curve to the right?
    119- What are the factors which shift oxygen-hemoglobin dissociation curve to the left?
    118- What is the meaning of shifting the oxygen-hemoglobin dissociation curve to the left?
    119- The hemoglobin contain iron in :
    - Ferrous form
    - Ferric form
    120- What is methemoglobin?
    121- What are the classification of aneamia?
    122- What are the causes of hypochromic microcytic aneamia?
    123- How the lead poisoning cause aneamia?
    124- What is the mechanism of sidroblastic aneamia?
    125- Is sideroblastic aneamia a type of hemolytic aneamia?
    126- What are the causes of hypochromic microcytic aneamia?
    127- What are the investigations you can use to differentiate between the causes of hypochromic microcytic aneamia?
    128- Where is the site of iron absorption ?
    129- Write five factors increase iron absorption?
    130- Write five factors decrease the absorption of iron?

    131- Which of the following conditions increase the daily requirements?
    a) Adult male
    b) Pregnant women
    c) Menstruating female
    d) Female( 12-16)

    132-Which of the following does NOT function in embryonic hemopoiesis?

    a) Yolk sac
    b) Liver
    c) Heart
    d) Bone Marrow
    e) Spleen



    138- How do red blood cells generate energy?
    a) Oxidation of carbohydrate, fat, protein, and alcohol
    b) Aerobic metabolism of glucose into pyruvate
    c) Breakdown of glucose via glucose decarboxylase
    d) Anaerobic metabolism of glucose to lactic acid
    e) Oxidative phosphorylation

    141- Which of the following types of anemia is generally normocytic?
    a) Pernicious anemia
    b) Sideroblastic anemia
    c) Anemia of chronic disease
    d) Iron deficiency anemia
    e) Sickle cell anemia
    142- Damage to the duodenum, preventing nutrient absorption, would cause which of the following forms of anemia?
    a) Deficiency of iron
    b) Deficiency of folic acid
    c) Deficiency of vitamin B12
    d) Deficiency of pyruvate kinase
    e) Deficiency of G6PD
    143- Damage to the ileum, preventing nutrient absorption, would cause which of the following forms of anemia?
    a) Deficiency of iron
    b) Deficiency of folic acid
    c) Deficiency of vitamin B12
    d) Deficiency of pyruvate kinase
    e) Deficiency of G6PD

    144- Damage to the jejunum, preventing nutrient absorption, would cause which of the following forms of anemia?
    a) Deficiency of iron
    b) Deficiency of folic acid
    c) Deficiency of vitamin B12
    d) Deficiency of pyruvate kinase
    e) Deficiency of G6PD


    145- Pernicious anemia is associated with:
    a) Vitamin K deficiency
    b) Vitamin C deficiency
    c) Vitamin B12 deficiency
    d) Folate deficiency
    e) Iron deficiency


    147-Which of the following would NOT be included on the differential diagnosis for hypochromic microcytic anemia?
    a) Sideroblastic anemia
    b) Anemia of chronic disease
    c) Iron deficiency anemia
    d) Thalassemia
    e) Pernicious anemia




    152- What is the primary cause of acute chest syndrome and pulmonary crisis in adults
    with sickle cell anemia?
    a) Salmonella
    b) Haemophilus
    c) Pneumococcus
    d) Mycoplasma
    e) Cell sickling


    153- -What is the most common cause of death in sickle cell disease in adult?
    a) Stroke
    b) Septicemia
    c) Uncontrollable bleeding
    d) Myocardial infarction
    e) Acute chest syndrome

    154- Patient has chest infection diagnosed as atypical pneumonia presented with aneamia and mild jaundice, which of the following type of aneamia most probably the cause?
    a) Megaloblastic aneamia
    b) Sickle cell aneamia
    c) Autoimmune hemolytic aneamia.
    d) Hereditary spherocytosis
    e) Thalassemia

    156-Thalassemia syndromes are due to:
    a) Qualitative defect in Hemoglobin synthesis.
    b) RBCs Enzymatic Deficiency.
    c) Deficient globin chain synthesis.
    d) Deficiency of the RBC structural protein( Spectrin)
    e) Defect in heam synthesis.



    158- The vitamin B12 is absorbed in the :
    a) Stomach.
    b) First part of duodenum
    c) Second part of duodenum
    d) Jejunum .
    e) Terminal ileum.

    162- What are the causes of iron deficiency aneamia?
    163- What is hemochromatosis?
    164- What are the causes of hemochromatosis?
    165- What are the causes of megaloblastic macrocytic aneamia?
    166- What are the causes of megaloblastic macrocytois?
    167- What are the causes of Vit B12 deficiency?
    168- What are the causes of folate deficiency?

    169- Mark the following statements( True/ False)
    - Perniciuos aneamia is a type of hemolytic aneamia?(T/F)
    - Perniciuos aneamia is a cause of megaloblastic aneamia?(T/F)
    - What are the antibodies used for diagnosis of pernicious aneamia?(T/F)
    - Which of these antibodies is specific and which are sensitive? (T/F)
    170- What are the investigations used for diagnosis of megaloblastic aneamia?
    171- In which condition hypersegmented neutrophiles, and giant metamyelocytes?
    172- What is schilling test?
    173- Write the classification of hemolytic anemia heridatary, or acquired?
    Hereditary, or acquired.
    174- Write the classification of hemolytic anemia to
    Intrinsic Extrinsic
    175- Write some examples of intravascular hemolytic anmia?
    176- Write some examples of extravascular hemolytic anmia?
    177- Write examples of hemolytic aneamia due to membrane defect?
    178- Write examples of hemolytic aneamia due to membrane defect?
    179- Write examples of hemolytic aneamia due to enzyme deficiency?
    180- Write examples of hemolytic aneamia due to hemoglobinopathy?
    181- Write the features of intravascular hemolysis?
    182- Gall bladder stones are commonly seen in ?
    a) Intravascular hemolysis.
    b) Extravascular hemolysis.
    183- Glucose 6- phosphate dehydrogenase deficiency is :
    a) Type of hereditary anemia.
    b) Cause intravascular hemolysis.
    c) X-linked
    d) Common in male.
    e) Common in female.
    184- Write comparison between cold and worm type autoimmune hemolytic anemia?
    185- Which is more common Worm type or cold type AIHA?
    186- Which of the following is due to acquired hemolytic anemia due membrane defect?
    a) Spherocytosis
    b) Elliptocytosis
    c) Paroxysmal nocturnal hemoglobinuria.

    187- What is EVANS syndrome?
    التعديل الأخير تم بواسطة أميرة يمنية; الساعة 22-06-2011, 06:09 PM.

  • #2
    وعليكم السلام والرحمة راح أحل لك الاسئلة اللي متأكده من إجاباتها وبالتوفييييييييييييييق ياارب




    3- List the three hemoglobins found in normal adult blood and state how much of each is present.
    [COLOR="darkorchid"] 1. Hb A 96-98% 2 alph&2 beta
    2. Hb A2 1.5-3.5% 2 alph & 2 delta
    3. Hb F less than 2% 2alph &2 gamma
    [/COLOR]
    4- Which hemoglobin is present in the highest amount in newborns?
    Hb F







    10- For each of the following RBC indices, write the formula for calculation and the normal reference range.
    a. MCV
    Hematocrit % x 10] /RBC ]
    NORMAL RANG 87+or- 5 femptoliters

    b. MCH
    HEMOGLOBIN % x 10] /RBC
    NORMAL RANGE 29 + OR - 2 PICOGRAMS
    11-



    12- What is the life span of a platelet?
    من سبعه الى عشرة أيام
    what the life span of RBC?


    14- What is the life spans of neutrophiles?

    من 12 الى 24 ساعه



    Monocytes؟
    من 20 الى 40 ساعه




    هذي الاسئلة اللي قدرت أساعدك في حلها وان شاء الله الاعضاء يحلولك الباقي بالتوفيييييييييق أختي

    تعليق


    • #3
      يسلمووووو

      وآلــف شــكر , , يعطيك العافيه

      آتمنى آجد حـل لبآقي الأسئله . ..

      تعليق


      • #4
        بلييييييييييييز

        ماباقي شئ عن الإمتحااااااااااان , , , آرجـــو إفـــآدتـــــي

        تعليق


        • #5
          فراشة ,,,ٍ سأحاول في حلها وأعود لك بالإجابات في مساء اليوم


          بس دعواتك معانا

          تعليق


          • #6
            ربي يوفقك ويسعدك

            مشكووور على مبآدرتك الطيبه

            تعليق

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