الدراسة الخامسة عشرا
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الباحث: أ / مها روحان عبده شمسان المقطري
الدرجة العلمية: ماجستير
الجامعة: جامعة صنعاء
الكلية: كلية الطب
بلد الدراسة: اليمن
تاريخ الإقرار: 2007
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Abstract
Syphilis, the third most common sexually transmitted disease after gonorrhea and Chlamydia, is caused by Treponema pallidum which is Gram negative, non cultivable bacterium, so the serological tests are the mainstay to diagnose syphilis.
A cross-sectional study was designed to determine the sero-prevalence of Treponema pallidum infection among selected groups in Sana'a city and to determine the risk factors that lead to infection.
During the period from August 2005 to August 2006, a total of 400 subjects were included in this study, 200 prisoners from Central Prison, Sana'a city, 98 pregnant women and 102 blood donors from different hospitals and clinical centers in Sana'a city.
Four hundred of blood samples were collected, and sera were tested to determine the presence of Treponema pallidum antibodies through two tests, the first was the screening test: Rapid plasma regain (RPR) to determines the presence of reagin antibodies, then only positive sera were tested again by the confirmatory test Treponema pallidum haemagglutionation test (TPHA) for detection of specific treponemal antibodies.
The sero-prevalence of Treponema pallidum infection (RPR positive /TPHA positive) was 2%, detected among prisoners group only.
There were statistically significant association between treponemal infection and age groups, educational level, history of operation and blood transfusion.Also, fever, abdominal pain and urinary tract infection were significantly associated with Treponema pallidum infection.
This study emphasizes the importance of using RPR as a screening test for high risk groups and the essential need of using TPHA as confirmatory test to eliminate biologically false positive cases.
معدل انتشار البكتريا اللولبية الشاحبة في مجاميع مختارة بمدينة صنعاء
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الباحث: أ / مها روحان عبده شمسان المقطري
الدرجة العلمية: ماجستير
الجامعة: جامعة صنعاء
الكلية: كلية الطب
بلد الدراسة: اليمن
تاريخ الإقرار: 2007
====
Abstract
Syphilis, the third most common sexually transmitted disease after gonorrhea and Chlamydia, is caused by Treponema pallidum which is Gram negative, non cultivable bacterium, so the serological tests are the mainstay to diagnose syphilis.
A cross-sectional study was designed to determine the sero-prevalence of Treponema pallidum infection among selected groups in Sana'a city and to determine the risk factors that lead to infection.
During the period from August 2005 to August 2006, a total of 400 subjects were included in this study, 200 prisoners from Central Prison, Sana'a city, 98 pregnant women and 102 blood donors from different hospitals and clinical centers in Sana'a city.
Four hundred of blood samples were collected, and sera were tested to determine the presence of Treponema pallidum antibodies through two tests, the first was the screening test: Rapid plasma regain (RPR) to determines the presence of reagin antibodies, then only positive sera were tested again by the confirmatory test Treponema pallidum haemagglutionation test (TPHA) for detection of specific treponemal antibodies.
The sero-prevalence of Treponema pallidum infection (RPR positive /TPHA positive) was 2%, detected among prisoners group only.
There were statistically significant association between treponemal infection and age groups, educational level, history of operation and blood transfusion.Also, fever, abdominal pain and urinary tract infection were significantly associated with Treponema pallidum infection.
This study emphasizes the importance of using RPR as a screening test for high risk groups and the essential need of using TPHA as confirmatory test to eliminate biologically false positive cases.
تعليق