ارجو ممن لديه اي معلومات عن Candidiasis ان لا يخل علينا بس يكون معلومات باللغة الانجليزية
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لا يوجد إعلان حتى الآن.
اي معلومات عن Candidiasis
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.Its fungal infection cause by candidia:sm194:
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مشكورين على الرد
ومشكورة مختبري مملكتي وانشاء الله اقدر ارد هذا الجميل
:sm188::sm188::sm188::sm188::sm188:
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Candidiasis and other yeast infections
Etiology: The major causative species are:
Candida albicans (> 50%)
C. parapsilosis
C. dubliniensis
C. tropicalis
C. krusei
C. glabrata
Trichosporon species
Malassezia furfur
Candidiasis
Definition
Candidiasis is a primary or secondary mycotic disease caused by a member of the genus Candida. The clinical manifestations may be acute, subacute or chronic. Involvement may be localized to the mouth, throat, skin, vagina, fingers, nails, bronchii, lungs or the gastrointestinal tract, or become systemic following candidemia
Occurrence
Part of naturally occurring microbial flora -skin, body orifices, gastrointestinal tract
Risk factors in Candidiasis)
(candidemia,disseminated disease
Broad-spectrum antibiotics, prolonged stay in ICU, intravascular catheters, gastro-intestinal surgery, malignancy, neutropenia, parenteral nutrition, extensive burns etc
Clinical forms of candidiasis
Superficial (mucocutaneous) candidiasis
a) Cutaneous infection
b) Chronic mucocutaneous infection
c) Onychomycosis
d) Oropharyngeal infection
e) Vulvovaginitis
f) Keratitis
g) Conjunctivitis
Deep candidiasis
a) Esophagitis
b) Gastrointestinal candidiasis
c) Urinary tract infection (includes “fungus ball of the ureter”, cystitis, renal abscess and pyelitis)
e) Peritonitis/intra-abdominal abscess
Hematogenously disseminated infection
a) Candidemia
b) Chronic disseminated (hepatosplenic) candidiasis
c) Suppurative phlebitis
d) Endocarditis
e) Meningitis
f) Endophthalmitis
g) Arthritis
h) Osteomyelitis
Main types of candidiasis
Oropharyngeal candidiasis
Includes thrush, glossitis, stomatitis and angular cheilitis (perleche). Thrush exhibits creamy gray membrane covering the tongue. Newborns (5%) commonly contact this by exposure to C. albicans in the vagina during delivery. Thrush is often associated with patients with severe immuonological impairment such as HIV, leukemia, and diabetes mellitus
Vulvovaginal candidiasis
Candida is one of the important causes of vulvovaginitis. The condition is characterized by a curd-like, milky vaginal discharge, often associated with broad-spectrum antibiotics, third trimester of pregnancy, low vaginal pH and diabetes mellitus. Refractory vaginal candidiasis may be associated with HIV/AIDS
Hepato-splenic candidiasis
Upper abdominal pain, fever, alkaline phosphatase elevated. CT-guided liver biopsy enhances the diagnosis if performed after the recovery from neutropenia.
Laboratory diagnosis
Vaginal candidiasisHigh vaginal swabs should be taken. Direct microscopy/ Gram-stained smear
reveals yeasts with pseudohyphae
CandidemiaBlood culture: Low sensitivity (repeat samples)[
Bactec system: (sensitivity is < 50%)
Lysis centrifugation (sensitivity is > 70%) and it has a lot of advantages: enhanced recovery (mean: 2.1 days), choice of medium, faster identification, and it is excellent for intracellular fungi (eg. Histoplasma, Candida )
Serological testsAntibody detection: Patients fail to make or sustain detectable response (exception Candida endocarditis). Good antibody response mark recovery. Lack of antibody indicates bad prognosis. May be present in normal individuals
Antigen detection: Cand-Tec Test (agglutination test): Sensitivity variable: 33% to 71%. Frequent sampling to raise sensitivity. A titer 1:4 or > has greater specificity. May be false negative in infections due to C. krusei, C. parapsilosis
Colony characteristics of Candida
Colonies are typically white to cream- colored with a smooth, glabrous to waxy surface. The specimen can be cultured on Sabouraud agar . Colonies usually appear with in 48 hours
Identification of Candida species
Germ tubes are filamentous outgrowths that emerge from a blastoconidium. Unlike pseudohyphae, the sides of the germ tubes are approximately parallel with no constrictions at the junction between germ tube and blastoconidium. C. albicans and C. dubliniensis are germ tube positive.
Germ-tube test: Positive for C. albicans and C. dubliniensis but not with other Candida species. to perform the test: small amount of the yeast cells mixed with 2ml of serum and incubated for about 3 hours at 370C. Microscopic examination should show tube-like structures emerging from the blastoconidia
Chlamydospores are large thick-walled vesicles with less protoplasm and help the fungus survive under harsh conditions. They may be intercalary, e.g., between blastoconidia of the pseudohyphae, or terminal on the pseudohyphae
Chlamydospore test on cornmeal-Tween 20 agar. The isolates of C. albicans and C. dubliniensis show this feature (chlamydospors are intracellularly) while other species do not
Carbohydrate assimilation tests
Lecture on mediacal microbiology by Dr. Z. U. Khan (October 2008). Kuwait University - Faculty of Allied Health Sciences – department of Medical Laboratory Sciences.
Note: Dr. Khan teachers mainly in faculty of medicine, but he give some lectures in faculty of Allied Health Sciences
تم بحمد الله مختصر محاضرة candidasis
أتمنى أنكم تستفيدوا منها
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التفريق بين الكانديدا الممرضة والغير ممرضه
فى الرابط ستجد الجواب الشافى ان شاء الله تعالى تقبل مرورى وادعى رالخير لصاحب الموضوع
http://www.arabslab.com/vb/showthread.php?t=9866
تقبل مرورى
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جزاكي الله كل خير أختي مختبري مملكتي تحياتي و احترامي لك
أخي الكريم هذا موضوع عن الكانديدا أضفته من خلال موضوع مستق حتى يشاهده الجميع
http://www.arabslab.com/vb/showthread.php?t=9875
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لا شكر على واجب
المشاركة الأصلية بواسطة gebrioفى الرابط ستجد الجواب الشافى ان شاء الله تعالى تقبل مرورى وادعى بالخير لصاحب الموضوع
http://www.arabslab.com/vb/showthread.php?t=9866
ازف اليكى تحياتى العطره يا مختبرجى مملكتى
تقبل مرورى
المشاركة الأصلية بواسطة أحمد مهدي بكورجزاكي الله كل خير أختي مختبري مملكتي تحياتي و احترامي لك
أخي الكريم هذا موضوع عن الكانديدا أضفته من خلال موضوع مستق حتى يشاهده الجميع
http://www.arabslab.com/vb/showthread.php?t=9875
المشاركة الأصلية بواسطة أسومةالله يعطيك العافية أختي "مختبري مملكتي "نتمنى نقدر إن نردلك الجميل:sm199:
الله يقدرنا.
سألت الله لكم التوفيق في الدنيا والآخرة
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