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The coronaviruses were originally grouped into the family Coronaviridae on the basis of the crown or halo-like appearance given by the glycoprotein-studded envelope on electron microscopy. This classification has since been confirmed by unique features of the chemistry and replication of these viruses. Most human coronaviruses fall into one of two groups: 229E-like and OC43-like. These differ in both antigenic determinants and culturing requirements: 229E-like coronaviruses can usually be isolated in human embryonic fibroblast cultures; OC43-like viruses can be isolated, or adapted to growth, in suckling mouse brain. There is little antigenic cross-reaction between these two types. They cause independent epidemics of indistinguishable disease. A new coronavirus, NL63, was recovered from a 7 month old child with bronchiolitis.
Figure 4: Electron micrograph of coronavirus
Figure 5: Schematic representation of coronavirus
Coronavirus organisation. A model of the coronavirus structure showing the organisation of the spike (3)2 membrane (M), and envelope (E) glycoproteins. The RNA is protected by a helical capsid of N protein monomers.
The coronaviruses were originally grouped into the family Coronaviridae on the basis of the crown or halo-like appearance given by the glycoprotein-studded envelope on electron microscopy. This classification has since been confirmed by unique features of the chemistry and replication of these viruses. Most human coronaviruses fall into one of two groups: 229E-like and OC43-like. These differ in both antigenic determinants and culturing requirements: 229E-like coronaviruses can usually be isolated in human embryonic fibroblast cultures; OC43-like viruses can be isolated, or adapted to growth, in suckling mouse brain. There is little antigenic cross-reaction between these two types. They cause independent epidemics of indistinguishable disease. A new coronavirus, NL63, was recovered from a 7 month old child with bronchiolitis.
Figure 4: Electron micrograph of coronavirus
Figure 5: Schematic representation of coronavirus
Coronavirus organisation. A model of the coronavirus structure showing the organisation of the spike (3)2 membrane (M), and envelope (E) glycoproteins. The RNA is protected by a helical capsid of N protein monomers.
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