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السلام عليكم
اود الاستفسار عن Bence jones protein
ولماذا ناخذ عينة ال urine .وعلى ماذا نبحث تحديدا في العينة
اود الاستفسار عن Bence jones protein
ولماذا ناخذ عينة ال urine .وعلى ماذا نبحث تحديدا في العينة
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Bence Jones protein
*A Bence Jones protein is a monoclonal globulin protein found in the blood or urine
*Finding this protein in the context of end-organ manifestations such as malignant bone marrow cancer, renal failure, lytic bone disease, or anemia, or large numbers of plasma cells in the bone marrow of patients can be diagnostic of multiple myeloma, in which it is present in 2/3 of cases
*The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells
*The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins. They are found in urine due to the kidneys' decreased filtration capabilities due to renal failure, often induced by hypercalcemia from the calcium released as the bones are destroyed
*The light chains can be detected by heating or electrophoresis of concentrated urine. Light chains precipitate when heated to 50 - 60 degrees C and redisolve at 90 -100 degrees C. These tests are essential in patients suspected of having Bence Jones proteins in their urine as these proteins don't react with the reagents normally utilized in urinalysis dipsticks. This leads to false negative results in people with Bence Jones proteins in their urine undergoing standard urinalysis. There are various rarer conditions that can produce Bence Jones proteins, such as Waldenström's macroglobulinemia and other malignances
قال رسول الله صلى الله عليه وسلم :
من سلك طريقاً يلتمس فيه علماً .. سهل الله له به طريقاً
إلى الجنه
لا خير في كاتم علم
يا حي يا قيوم برحمتك أستغيث أصلح لي شأني كله و لا تكلني إلى نفسي طرفة عين
مع أطيب التمنياتCAESAR22 -
هو abnormal protien يظهر في بعض سرطانات الدم مثل multiple myeloma يسمي abnormal paraprotien
ويظهر في البول لان وزنه الجزيئي صغير حوالى 40000 - 50000 k daltonإذا أردت أن تعيش سعيداً .. إنزع الحقد من قلبكتعليق
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