السلام عليكم حبيت اكتب عن موضوع
LFTs وياريت يعجبكم وتستفيدوا منه ان شاء الله اولا احب اشير لحاجه هامه جدا مش معنى اى ريبورت يجى المعمل عاوزنى اعمل LFTs يبقى GOT & GPT لاءه طبعا لان التحاليلن دول مختصين بس لو كان فى damage to the liver cell طب افرض ان المشكله فى الكبد كانت فى Synthetic function يبقى بقى مش هتعمل GOT & GPT المفروض لو الدكتور اللى طالب التقرير شاكك ان وظائف الكبد الاخراجيه فيها مشكله هيقولك اعملى عن Prothrombin time & Plasma albumin وبرده لو كان المريض يعانى من مشاكل فى الوظائف الاخراجيه Exceratroy function يبقى المفروض التقرير يطون مطلوب فيه حاجتين اسمهم
Alkaline Phosphatase & Gamma glutamyl transferase
وظائف الكبد :-
Metablioc function :-
تحويل الزياده فى تركيز السكر الى جليكوجين وهيكل كربونى لاحماض دهنيه تنقل الى الخلايا الدهنيه لكى تخزن فى صوره ليبوبروتين .
اثناء الصيام يقوم الكبد بالحفاظ ع نسبه السكر المطلوبه فى الجسم عن طريق تحويل الجليكوجين الى سكر وهذه العمليه تسمى glycogenolysis اوتصنيع الجلوكوز من اى مصدراخر زى مثلا الاحماض الامينيه .
Synthetic function :-
تصنيع البلازما بروتين مثل الالبيومين ماعدا بروتينات ال Ig & complement اللى فى المناعه.
معظم عوامل التجلط
Excretion & Detoxification :-
يتم اخراج المواد الضاره من الجسم عن طريق الكبد مثل :
Amino gruop ناتجه من الاحماض الامينيه والتى يتم نزعها منها فى الكبد ويتم اخراجها على صوره يوريا .
cholesterol يتم التخلص منها عن طريق الصفرا .
steroid hormones يتم التخلص منها مع البول .
drugs يتم التخلص من بعضها عن طريق الصفرا .
toxins يتم التخلص منها عن طرق خلايا فى الكبد تسمى Kupffer cells .
اخير bilirubin.
هذه بعض من الاختبارات الخاصه بالكبد والتى كما ذكرت تعتمد اولا واخيرا ع التشخيص السليم للدكتور هل اذا كانت الحاله الى قدامه بتعانى من تحطم فى خليه الكبد نفسها او عيب اخراج او تصنيع . الدكاتره بقى بيريحو ا نفسهم ويقولك اعملى تحاليل كبد شامل علشان يريح نفسه بس فى نفس الوقت ده زياده تكاليف ع المريض وبالتالى اخصائى التحاليل يقولك ادفع ياحلو ......
اولا الاختبارات الخاصه ب Cell Damage :-
Alanine transaminase ALT U/L (5 to 45).
Also called as Serum Glutamic Pyruvic Transaminase (SGPT). ALT is an enzyme present in hepatocytes (liver cells). When a cell is damaged, it leaks this enzyme into the blood, where it is measured. ALT rises dramatically in acute liver damage, such as viral hepatitis.All types of liver inflammation can cause raised ALT. Liver inflammation can be caused by fatty infiltration (see fatty liver) some drugs/medications, alcohol, liver and bile duct disease.
2-Aspartate aminotransferase AST U/L (5 to 45).
Also called as Serum Glutamic Oxaloacetic Transaminase (SGOT). This is a mitochondrial enzyme that is also present in heart, muscle, kidney and brain therefore it is less specific for liver disease. AST is similar to ALT in that it is another enzyme associated with liver parenchymal cells. It is raised in acute liver damage. It is also present in red cells and cardiac muscle. In many cases of liver inflammation, the ALT and AST activities are elevated roughly in a 1:1 ratio.
ثانيا الاختبارات الخاصه ب Synthetic Function :-
1-Prothrombin time (PT). Seconds (11 to 13.5) .
The prothrombin time is tested to evaluate disorders of blood clotting, usually bleeding. It is a broad screening test for many types of bleeding disorders. When the liver is damaged it may fail to produce blood clotting factors.
2-Albumin (Alb). g/L (38-55)
A major protein formed by the liver. It is the main constituent of total protein; the remaining fraction is called globulin. It is the major protein that circulates in the bloodstream. As it is made by the liver and secreted into the blood it is a sensitive marker and a valuable guide to the severity of liver disease. And chronic liver disease causes a decrease in the amount of albumin produced. Albumin levels are decreased in chronic liver disease, such as cirrhosis. It is also decreased in nephrotic syndrome, where it is lost through the urine.
ثالثا الاختبارات الخاصه ب Excretory function :-
1-Alkaline Phospahte U/L (30 to 120).
It is an enzyme in the cells lining the biliary ducts of the liver. If there is an obstruction in the bile duct, e.g. gallstones, ALP levels in plasma will rise. ALP is also present in bone and placental tissue, so it is higher in growing children (as their bones are being remodelled).Conditions such as Primary Biliary Cirrhosis and Sclerosing Cholangitis will generally show a raised AP. Raised levels may also occur in cirrhosis and liver cancer.
2-Gamma glutamyl transpeptidase (GGT). U/L (5 to 35).
Although reasonably specific to the liver and a more sensitive marker for cholestatic damage than ALP, Gamma glutamyl transpeptidase (GGT) may be elevated with even minor, sub-clinical levels of liver dysfunction. It can also be helpful in identifying the cause of an isolated elevation in ALP. GGT is raised in alcohol toxicity (acute and chronic). GT is often elevated in those who usealcohol or other liver toxic substances to excess. GGT is also induced by many drugs, including alcohol, therefore often when the AP is normal a raised GGT can often (but not always) indicate alcohol use. Raised GGT can often be seen in cases of fatty liver and also where the patient consumes large amounts of Aspartame (artificial Sweetener) in diet drinks for example.
ارجو انى اكون وفقت فى العرض البسيط ده ل LFTs
لا تنسونا من صالح الدعاء
LFTs وياريت يعجبكم وتستفيدوا منه ان شاء الله اولا احب اشير لحاجه هامه جدا مش معنى اى ريبورت يجى المعمل عاوزنى اعمل LFTs يبقى GOT & GPT لاءه طبعا لان التحاليلن دول مختصين بس لو كان فى damage to the liver cell طب افرض ان المشكله فى الكبد كانت فى Synthetic function يبقى بقى مش هتعمل GOT & GPT المفروض لو الدكتور اللى طالب التقرير شاكك ان وظائف الكبد الاخراجيه فيها مشكله هيقولك اعملى عن Prothrombin time & Plasma albumin وبرده لو كان المريض يعانى من مشاكل فى الوظائف الاخراجيه Exceratroy function يبقى المفروض التقرير يطون مطلوب فيه حاجتين اسمهم
Alkaline Phosphatase & Gamma glutamyl transferase
وظائف الكبد :-
Metablioc function :-
تحويل الزياده فى تركيز السكر الى جليكوجين وهيكل كربونى لاحماض دهنيه تنقل الى الخلايا الدهنيه لكى تخزن فى صوره ليبوبروتين .
اثناء الصيام يقوم الكبد بالحفاظ ع نسبه السكر المطلوبه فى الجسم عن طريق تحويل الجليكوجين الى سكر وهذه العمليه تسمى glycogenolysis اوتصنيع الجلوكوز من اى مصدراخر زى مثلا الاحماض الامينيه .
Synthetic function :-
تصنيع البلازما بروتين مثل الالبيومين ماعدا بروتينات ال Ig & complement اللى فى المناعه.
معظم عوامل التجلط
Excretion & Detoxification :-
يتم اخراج المواد الضاره من الجسم عن طريق الكبد مثل :
Amino gruop ناتجه من الاحماض الامينيه والتى يتم نزعها منها فى الكبد ويتم اخراجها على صوره يوريا .
cholesterol يتم التخلص منها عن طريق الصفرا .
steroid hormones يتم التخلص منها مع البول .
drugs يتم التخلص من بعضها عن طريق الصفرا .
toxins يتم التخلص منها عن طرق خلايا فى الكبد تسمى Kupffer cells .
اخير bilirubin.
هذه بعض من الاختبارات الخاصه بالكبد والتى كما ذكرت تعتمد اولا واخيرا ع التشخيص السليم للدكتور هل اذا كانت الحاله الى قدامه بتعانى من تحطم فى خليه الكبد نفسها او عيب اخراج او تصنيع . الدكاتره بقى بيريحو ا نفسهم ويقولك اعملى تحاليل كبد شامل علشان يريح نفسه بس فى نفس الوقت ده زياده تكاليف ع المريض وبالتالى اخصائى التحاليل يقولك ادفع ياحلو ......
اولا الاختبارات الخاصه ب Cell Damage :-
Alanine transaminase ALT U/L (5 to 45).
Also called as Serum Glutamic Pyruvic Transaminase (SGPT). ALT is an enzyme present in hepatocytes (liver cells). When a cell is damaged, it leaks this enzyme into the blood, where it is measured. ALT rises dramatically in acute liver damage, such as viral hepatitis.All types of liver inflammation can cause raised ALT. Liver inflammation can be caused by fatty infiltration (see fatty liver) some drugs/medications, alcohol, liver and bile duct disease.
2-Aspartate aminotransferase AST U/L (5 to 45).
Also called as Serum Glutamic Oxaloacetic Transaminase (SGOT). This is a mitochondrial enzyme that is also present in heart, muscle, kidney and brain therefore it is less specific for liver disease. AST is similar to ALT in that it is another enzyme associated with liver parenchymal cells. It is raised in acute liver damage. It is also present in red cells and cardiac muscle. In many cases of liver inflammation, the ALT and AST activities are elevated roughly in a 1:1 ratio.
ثانيا الاختبارات الخاصه ب Synthetic Function :-
1-Prothrombin time (PT). Seconds (11 to 13.5) .
The prothrombin time is tested to evaluate disorders of blood clotting, usually bleeding. It is a broad screening test for many types of bleeding disorders. When the liver is damaged it may fail to produce blood clotting factors.
2-Albumin (Alb). g/L (38-55)
A major protein formed by the liver. It is the main constituent of total protein; the remaining fraction is called globulin. It is the major protein that circulates in the bloodstream. As it is made by the liver and secreted into the blood it is a sensitive marker and a valuable guide to the severity of liver disease. And chronic liver disease causes a decrease in the amount of albumin produced. Albumin levels are decreased in chronic liver disease, such as cirrhosis. It is also decreased in nephrotic syndrome, where it is lost through the urine.
ثالثا الاختبارات الخاصه ب Excretory function :-
1-Alkaline Phospahte U/L (30 to 120).
It is an enzyme in the cells lining the biliary ducts of the liver. If there is an obstruction in the bile duct, e.g. gallstones, ALP levels in plasma will rise. ALP is also present in bone and placental tissue, so it is higher in growing children (as their bones are being remodelled).Conditions such as Primary Biliary Cirrhosis and Sclerosing Cholangitis will generally show a raised AP. Raised levels may also occur in cirrhosis and liver cancer.
2-Gamma glutamyl transpeptidase (GGT). U/L (5 to 35).
Although reasonably specific to the liver and a more sensitive marker for cholestatic damage than ALP, Gamma glutamyl transpeptidase (GGT) may be elevated with even minor, sub-clinical levels of liver dysfunction. It can also be helpful in identifying the cause of an isolated elevation in ALP. GGT is raised in alcohol toxicity (acute and chronic). GT is often elevated in those who usealcohol or other liver toxic substances to excess. GGT is also induced by many drugs, including alcohol, therefore often when the AP is normal a raised GGT can often (but not always) indicate alcohol use. Raised GGT can often be seen in cases of fatty liver and also where the patient consumes large amounts of Aspartame (artificial Sweetener) in diet drinks for example.
ارجو انى اكون وفقت فى العرض البسيط ده ل LFTs
لا تنسونا من صالح الدعاء
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