تويت
- Clostridium tetani : Bacteria of the family Clostridium SPP Of a
group gram positive
bacilli
Characteristics
larg Gr+ Ve bacilli
sporing , motile bacilli
Clostridium tetani
spores are spherical , terminal ( drumstick )
non capsulate bacilli
obligate anaerobes
difficult to grow.because the organism is extremely sensitive
to oxygen toxicity.
Not ferment carbohydrates.
Habitat
- soil & commensal in intestinal tract of animal .
- spore remain viable after dry heat up to 160 C for 1 hour .
Transmission
- Via major or minor wounds .
Pathogenesis
tetanolysin ( exotoxin) = lyses erythrocytes .
tetanospasmin ( exotoxin ) = neurotoxin that affects CNS
causing muscular rigidty and spasns .
spore formation.
tetanus ( human & animals) :-
generalized tetanus
localized tetanus
neonatal tetanus
swarming colonies on blood agar
detection of neurotoxin by serological method .
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التعديل الأخير تم بواسطة فتى الخفجي; الساعة 04-02-2012, 12:21 AM.