Osmotic fragility is a test to detect red blood cells that are more fragile than normal.
Low osmotic fragility (increased resistance to hemolysis) is characteristic of thalassemia, iron deficiency anemia, sickle cell anemia, and other red cell disorders in which codocytes (target cells) and leptocytes are found. Low osmotic fragility also occurs after splenectomy.
High osmotic fragility (increased tendency to hemolysis) occurs in hereditary spherocytosis, in spherocytosis associated with autoinunune hemolytic anemia, severe burns, or chemical poisoning, or in hemolytic disease of the newborn (erythroblastosis fetalis).
becouse they are having abnormal haemoglobin chage the RBCs shape to oval or pencil like cell or sickle cell the opposite in sherocytosis they are more rounded cells
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