:
-Introduction:
This study has been done during the period from March to July 2012 which was carried out in the central laboratories building of Al-Zaiem Al-Azhari University and Khartoum Teaching Hospital.
The study aimed to evaluate the measurement, accuracy and precision of the common PT reagents coming from different companies (TEclot, futura System, Stago and Fortress) used in Khartoum state laboratories.
-Material and Method:
This study was descriptive comparative study done in (twenty nine) patients under oral anticoagulant therapy taken from Sudan Heart Center Hospital for comparing if there are difference of results between the four companies, using Quick and Owren manual method. In addition to human control sera which obtained from Tech-noclot Company for evaluating their quality in accuracy and precision according to reference result, using automated (sysemx ca-500)
-Result:
This study showed that PT reagents have different result for the same patients samples either in control sera the reading showed statistical difference of the PT result between all the companies except between Stago company and TEclot company which there are no significant difference. Furthermore calculation of the INR patient’s results showed there are significant difference between all companies expect TEclot Company and Fortress.
In addition our results showed the most accurate company is Fortress (INR=1), and the other companies gave acceptable results according to reference Value (0.91-1.09) expect futura System Company which have significant difference to control value (1.16).
-Discussion:
This study showed there are statistical difference between PT reagents manufactured by different companies which apparently agreed with previous studies of Nancy Grove study, Kristine Rotzoll study The University of Iowa Hygienic Laboratory. Also we found that there was the average of accuracy and precision differ between all companies.