ABSTRACT
The aim of this study is to assess common organisms causing Urinary Tract Infection (UTI) in Gaza Strip, Palestine and to examine the incidence of ciprofloxacin resistance in the strains of bacteria isolated from patients suspected with UTI during January to June (2004). Ciprofloxacin was evaluated along with other commonly used antibiotics against a total of 480 clinical isolates obtained from urine samples. The samples were collected from outdoor patients from different parts of Gaza Strip. Susceptibility tests were done by the Kerby Bauer method. Among the tested drugs, the percent resistance rates observed were: 15.0% to ciprofloxacin, 82.5% to amoxycillin, 64.4% to cotrimoxazole, 63.1% to doxycycline, 32.5% to cephalexin, 31.9% to nalidixic acid and 10.0% to amikacin. However, high resistance to ciprofloxacin was detected among Acinetobacter haemolyticus (28.6%), Staphylococcus saprophyticus (25.0%), Pseudomonas aeruginosa (20.0%), Klebsiella pneumonia (17.6%) and Escherichia coli (12.0%). Minimal inhibitory concentration (MIC) of ciprofloxacin was measured for all resistant UTI isolates. This study indicates emerging ciprofloxacin resistance among most UTI bacterial pathogens. Increasing resistance against ciprofloxacin demands coordinated monitoring of its activity and rational use of the antibiotics.
The aim of this study is to assess common organisms causing Urinary Tract Infection (UTI) in Gaza Strip, Palestine and to examine the incidence of ciprofloxacin resistance in the strains of bacteria isolated from patients suspected with UTI during January to June (2004). Ciprofloxacin was evaluated along with other commonly used antibiotics against a total of 480 clinical isolates obtained from urine samples. The samples were collected from outdoor patients from different parts of Gaza Strip. Susceptibility tests were done by the Kerby Bauer method. Among the tested drugs, the percent resistance rates observed were: 15.0% to ciprofloxacin, 82.5% to amoxycillin, 64.4% to cotrimoxazole, 63.1% to doxycycline, 32.5% to cephalexin, 31.9% to nalidixic acid and 10.0% to amikacin. However, high resistance to ciprofloxacin was detected among Acinetobacter haemolyticus (28.6%), Staphylococcus saprophyticus (25.0%), Pseudomonas aeruginosa (20.0%), Klebsiella pneumonia (17.6%) and Escherichia coli (12.0%). Minimal inhibitory concentration (MIC) of ciprofloxacin was measured for all resistant UTI isolates. This study indicates emerging ciprofloxacin resistance among most UTI bacterial pathogens. Increasing resistance against ciprofloxacin demands coordinated monitoring of its activity and rational use of the antibiotics.
تعليق