إعـــــــلان

**bhloool** · 06-09-2009, 12:46 AM

Hi
80- C
81- i can't choose only one answer
in B the distribution can be pancellular or heterocellular
in D there r 2 types of this disorder depending on the molecular defect:
one result from long deletions of β− globulin gene cluster. in this type ur statment is correct.
the other result from point mutation in the promoter region of γ− globulin genes which allow γ− genes to be active in the adult life and the β gene also remain active
maybe i didn't understand the question please Dr.ashraf correct my informations if wrong
and deep sorry for prolongation
:sm184::sm184:

**m^rm^r** · 06-09-2009, 02:52 AM

D
D
--------------------------
:sm195:

**ashraf shaq** · 06-09-2009, 11:23 PM

F cells are adult red cells that are still being able to synthesize Hb-F
not all red cells are able to do so, so RBCs which are still being able to do so are called F cells.
Homogenous or pancellular means here that all cells are F cells, which means these are cells which all of them are able to synthesize Hb-F

**ashraf shaq** · 06-09-2009, 11:29 PM

الاجابات الصحيحة ليوم السبت 5/9/2009

المشاركة الأصلية بواسطة ashraf shaq مشاهدة المشاركة

اسئلة اليوم السبت 5/9/2009 هم:

80- Calculate the corrected WBC count, if applicable, given the following results: TWBC= 45x109/L, NRBC/100WBC= 7.
A- ~24x109/L
B- ~33x109/L
C- ~39x109/L
D- ~41x109/L
E- Not applicable
Because you will correction only when there is more or equal to 10 NRBC, here in our question it is 7 only, so you will not do correction, and the TWBC will remain the same 45.

81- In HPFH(Hereditary persistance of Hb-F), which is a false statement:
A- All cells are F cells
B- There is a pancellular distribution of HbF
C- Homozygotes have only HbF
D- Expressing β-globin genes at the same level in adult life as in fetal life
E- All cells contain HbF

موفقين بالاجابة

وموفقين في اسئلة اليوم يا جماعة وين المشاركة يلا شاركو

**ashraf shaq** · 07-09-2009, 02:38 AM

الأسئلة الجديدة لليوم الأحد هي:

1- Which leukemia is largely associated with DIC
2- Which leukemia is associated with t(15;17), translocation
3- what is the resultant of this translocation
4- is this leukemia is curable or not
5-what is the drug of choice to treat this leukemia
6- how many forms does this leukemia have
does auer rods are associated with this type of leukemia7-

موفقين

**mohammad aboghabsha** · 07-09-2009, 02:48 AM

m3===1
m3===2
3=====
4====curable
5=====
6====2forms M3&M3varient
7=====yes

**m^rm^r** · 07-09-2009, 03:52 AM

اعتقد سبع انواع من AMرL
اريد الفرق بين ثلاسيميا الفا وبيتا و سمحت يادكتور

**hematologist** · 07-09-2009, 05:52 PM

1- Promyeloctyic Leukemia M3

2- Acute promyelocytic leukemia

3- The resultant fusion proteins disrupt the function of retinoic acid receptor-alpha (RARα) gene which blocks the normal maturation of granulocytes. Although the chromosomal translocation involving RARα is believed to be the initiating event, additional mutations are required for the development of leukemia.

4- curable

5- Allogeneic stem cell transplant is a treatment option in APL. Remission with use of arsenic trioxide has been reported

6- M3 AND M3 VARIENT

7- YES

**ashraf shaq** · 07-09-2009, 07:55 PM

الاجابات الصحيحة ليوم الأحد

اجابات أسئلة يوم الأحد هي:

1-

Which leukemia is largely associated with DIC
Acute Promyelocytic Leukemia (AML-M3), even if the case is diagnosed as M3 and DIC is not apparent it should be beared in mind that DIC may develop. DIC develop in this type of leukemia because the granules of promyelocytes contain procaogulant materials, when promyelocytes degranulate it releases these procoagulant substances.

2- Which leukemia is associated with t(15;17), translocation
Also acute promyelocytic leukemia (AML-M3) is associated with this type of leukemia.

3- what is the resultant of this translocation
The resultant is a fusion between 2 genes RAR/PML fusion genes with a chimeric protein product. That block maturation of promyelocytes beyond this stage of development.

4- is this leukemia is curable or not
It is curable

5-What is the drug of choice to treat this leukemia
The drug of choice is ATRA (All Trans alpha Retinoic Acid
6- how many forms does this leukemia have
Two forms the hypergranular type and hypogranular type, M3 and M3v respectively

does auer rods are associated with this type of leukemia7-
Yes auer rods can be associated with this type of leukemia, even multiple auer rods in one cell, and the cell with multiple auer rods is called Fagott cell.

موفقين

**ashraf shaq** · 07-09-2009, 08:03 PM

الأسئلة الجديدة ليوم الاثنين هي:

84- A patient has a macrocytic anemia. A BM aspirate is obtained and examined. The marrow is 80% cellular and the M:E ratio is 1: 2. These findings indicate:
A- Aplastic BM
B- Increased fat to cell ratio.
C- Dysplastic BM.
D- Increased leukopoiesis.
E- Non of the above.

85- What is the RPI given the following: Hb 15 g/dl, Hct 44%, retic count 1.2%?
A- 4.27
B- 1.7
C- 2.9
D- 1.0
E- Not applicable

86- The morphologic classification of anemia depends on:
A- Degree of anisopoikilocytosis.
B- Size and color of RBCs.
C- Pathophysiologic cause of anemia.
D- Variation in shape of RBCs.
E- MCV

موفقين ان شاء الله،،،،،

**hematologist** · 07-09-2009, 11:41 PM

84- E

85- E

86- B

**bhloool** · 08-09-2009, 12:08 AM

84- E
85- E
86- B

**m^rm^r** · 08-09-2009, 06:32 PM

D
E
B
----------------------------------------------------

**ashraf shaq** · 08-09-2009, 08:50 PM

الاجابات الصحيحة ليوم الاثنين

المشاركة الأصلية بواسطة ashraf shaq مشاهدة المشاركة

الأسئلة الجديدة ليوم الاثنين هي:

84- A patient has a macrocytic anemia. A BM aspirate is obtained and examined. The marrow is 80% cellular and the M:E ratio is 1: 2. These findings indicate:
A- Aplastic BM
B- Increased fat to cell ratio.
C- Dysplastic BM.
D- Increased leukopoiesis.
E- Non of the above.

85- What is the RPI given the following: Hb 15 g/dl, Hct 44%, retic count 1.2%?
A- 4.27
B- 1.7
C- 2.9
D- 1.0
E- Not applicable
this a normal subject why doing RPI or coorection to retics

86- The morphologic classification of anemia depends on:
A- Degree of anisopoikilocytosis.
B- Size and color of RBCs.
C- Pathophysiologic cause of anemia.
D- Variation in shape of RBCs.
E- MCV

موفقين ان شاء الله،،،،،

ان شاء الله تكونوا استفدتوا...................................

**ashraf shaq** · 09-09-2009, 10:47 PM

الأسئلة الجديدة لليوم الثلاثاء هم:

87- In vacuum tube (vacutainer®) tube system, the red top tube contains:
A] EDTA
B] Sodium Fluoride
C] Potassium oxalate
D] Nothing it is a plain tube
E] Heparin

88- In a blood film, PMN tend to accumulate in the:
A] Feathered end
B] Thick area
C] Thin area
D] Monolayer zone
E] Edges

89- Heparin as in vitro anticoagulant will act by:
A] Precipitating calcium.
B] Complexing with mucopolysaccharides.
C] Inhibiting platelet function.
D] Chelating calcium ions.
E] Binding to antithrombin

90- To correct erroneous hemoglobin results caused by persistent lipemia, your action will be:
A] Preparing a sample blank
B] Obtaining 14 hours fasting blood sample from the patient
C] Centrifuging patient blood sample, and collecting the supernatant for hemoglobin determination
D] Requesting the patient not to eat high protein meal for 3 days prior testing
E] Do a standard curve and derive patient hemoglobin concentration

91- Erroneous manual HCT determination can be caused by
A] Adequate mixing of the blood
B] Inclusion of buffy coat height in calculations
C] Reduced trapped plasma
D] Normocytic RBCs
E] Extracentrifugation time

92- All of the following will affect ESR results, EXCEPT:
A] RBC size
B] Globulin concentration
C] Presence of poikilocytes
D] Fibrinogen concentration
E] Non of the above

93- A highly comparable red cell parameter between automated cell counters and manual hematology is the:
A] MCV
B] MCH
C] MCHC
D] RDW
E] MCHC

موفقين بالاجابات،،،،،،

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